Adam Sandler

as George Simmons

Born 09/09/1966, age

Seth Rogen

as Ira Wright

Born 04/15/1982, age

Leslie Mann

as Laura

Born 03/26/1972, age

Eric Bana

as Clarke

Born 08/09/1968, age

Jonah Hill

as Leo Koenig

Born 12/20/1983, age

Jason Schwartzman

as Mark Taylor Jackson

Born 06/26/1980, age

Aubrey Plaza

as Daisy Danby

Born 06/26/1984, age

RZA

as Chuck

Born 07/05/1969, age

Aziz Ansari

as Randy

Born 02/23/1983, age

Maude Apatow

as Mable

Born 12/15/1997, age

Iris Apatow

as Ingrid

Born 10/12/2002, age

Allan Wasserman

as Dr. Stevens

Born 05/16/1952, age

James Taylor

as James Taylor

Born 03/12/1948, age

Nicole Parker

as Dawn

Born 02/21/1978, age

Andy Dick

as Andy Dick

Born 12/21/1965, age

Charles Fleischer

as Charles Fleischer

Born 08/27/1950, age

George Coe

as George's Dad

Born 05/10/1929

Died 07/18/2015, age

Paul Reiser

as Paul Reiser

Born 03/30/1957, age

Norm Macdonald

as Norm Macdonald

Born 10/17/1959

Died 09/14/2021, age

Sarah Silverman

as Sarah Silverman

Born 12/01/1970, age

Maggie Siff

as Rachel

Born 06/21/1974, age

Eminem

as Eminem

Born 10/17/1972, age

Ray Romano

as Ray Romano

Born 12/21/1957, age

Bo Burnham

as Yo Teach Cast Member

Born 08/21/1990, age

Carla Gallo

as Miss Pruitt on Yo Teach

Born 06/24/1975, age

Justin Long

as Re-Do Guy

Born 06/02/1978, age

Dan Harmon

as Paparazzi at Medical Center

Born 01/03/1973, age

Orny Adams

as Orny Adams

Born 11/10/1970, age

Janeane Garofalo

as Friend in video (archive footage) (uncredited)

Born 09/28/1964, age

Ben Stiller

as Friend in video (archive footage) (uncredited)

Born 11/30/1965, age

Judd Apatow

as Friend in video (voice) (archive footage) (uncredited)

Born 12/06/1967, age